Active sitting is likely to substantially enhance the health and wellbeing of office workers. It can help provide regular core muscle activation and strengthening, and may also help in the rehabilitation of structural deficits to the muscle and its nerve after injury. Exercises involving core muscle strengthening, motor control and/or balance training can stimulate better brain-based (endogenous) pain modulation. And training the spinal muscles through active sitting is likely to produce better pain-gating for people with back pain.